Experimental models of inflammation in laboratory animals

Sepsis Models in Experimental Animals

Sepsis develops as a common inflammatory response to various infections. It runs with the picture of a complex heterogeneous syndrome which often leads to the development of multiple organ dysfunctions and causes the death of millions of people worldwide. For various reasons, detailed research of sepsis in humans is difficult to conduct; therefore, a lot of efforts have been made to model it. P...

Activity of terbinafine in experimental fungal infections of laboratory animals.

The allylamine derivative terbinafine is the first antifungal agent with primary fungicidal properties against dermatophytes which acts systemically after oral application as well as locally after topical application. Comparative oral studies carried out with griseofulvin and ketoconazole in model infections such as guinea pig trichophytosis and microsporosis revealed terbinafine to be superior...

Scorpion Venom Pisoning in Experimental Animals

In silico models of acute inflammation in animals.

Trauma and hemorrhagic shock elicit an acute inflammatory response, predisposing patients to sepsis, organ dysfunction, and death. Few approved therapies exist for these acute inflammatory states, mainly due to the complex interplay of interacting inflammatory and physiological elements working at multiple levels. Various animal models have been used to simulate these phenomena, but these model...

Making Animals Alcoholic: Shifting Laboratory Models of Addiction

The use of animals as experimental organisms has been critical to the development of addiction research from the nineteenth century. They have been used as a means of generating reliable data regarding the processes of addiction that was not available from the study of human subjects. Their use, however, has been far from straightforward. Through focusing on the study of alcoholism, where the n...